Tapentadol is approximately two to three times more potent than tramadol and two to three times less potent than morphine.

Tapentadol, brand names Nucynta among others, is a centrally acting opi@id analgesic of the benzenoid class with a dual mode of action as an agonist of the μ-opioid receptor and as a norepinephrine reuptake inhibitor. Analgesia occurs within 32 minutes of oral administration, and lasts for 4–6 hours. Wikipedia

Other names: BN-200; CG-5503; R-331333

Metabolism: Hepatic (mostly via glucuronidation but also by CYP2C9, CYP2C19, CYP2D6)

Bioavailability: 32% (oral)

Excretion: Urine and faeces (1%)

Protein binding: 20%

AHFS/Drugs.com: Monograph

Elimination half-life: 4 hours< (duration 4-6 hours)